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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2018
  5. Science Group Updates
  6. Imaging and Microscopy Group

Imaging and Microscopy Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Paul Quinn, Science Group Leader

Update

Imaging and Microscopy is a newly formed science group, which brings together eight experimental facilities (I08, J08, DIAD, I12, I13-1, I13-2, I14 and ePSIC) with a new imaging group leader to coordinate and drive the group’s activities. These facilities use electrons and X-rays to image samples under different experimental conditions across a diverse range of length scales and time scales. Different contrast mechanisms allow for imaging of sample properties such as elemental composition, density and structure and this ability to extract image sample properties in minute detail lends itself to a wide range of scientific areas from chemistry and catalysis to environmental science, materials science, biology, medicine, and cultural heritage. Read more ...

Highlights

  • annual review
    Revealing the reactivity of iron in the Lena River basin

    Revealing the reactivity of iron in the Lena River basin Jun 1, 2018

    With the melting Arctic ice cap causing its rivers to swell, understanding how organic carbon (C) is transported to the ocean and crucially trapped by these rivers is important for climate change modelling and mitigation.

  • annual review
    State-of-the-art electron microscopy offers clarity on diamond defects

    State-of-the-art electron microscopy offers clarity on diamond defects Jun 1, 2018

    Flawless diamonds are extremely rare and expensive. Most diamonds contain defects, and for scientific and industrial applications, the defects are very important. In a naturally-formed diamond, the presence and structure of defects can be used to accurately determine the geological environment in which it was formed. The defects also shape the electronic and optical properties of diamonds, and exploiting these properties in synthetic diamonds could lead to next-generation optical storage ...

  • annual review
    Imaging multiphase fluid flow in permeable media

    Imaging multiphase fluid flow in permeable media Jun 1, 2018

    Knowing how fluids move through micron-sized voids (or ‘pores’) in rock kilometres below the Earth’s surface is crucial information to help understand and optimise underground carbon dioxide (CO2) sequestration, oil recovery from reservoir rocks, and a host of other processes.

  • annual review
    Corrective glasses provide sharper X-ray vision

    Corrective glasses provide sharper X-ray vision Jun 1, 2018

    The intense X-ray light produced by modern synchrotron radiation sources and X-ray free-electron lasers (XFELs) allows the fine structure and dynamics of matter to be studied in exquisite detail. In principle, beams should be able to be focused to a few nanometres and below.

  • annual review
    Investigating lithium ion battery failures

    Investigating lithium ion battery failures Jun 1, 2018

    The 18650 cylinder is the most widely used lithium ion (Li-ion) cell geometry, powering everything from laptops to electric vehicles. Its capacity has been steadily increasing, and now more than ever, the safety of Li-ion batteries is of the utmost importance. Cell failure is extremely rare during normal operation, but under abusive conditions the active materials within Li-ion batteries break down exothermically, generating large amounts of heat that can lead to a positive feedback loop, ...

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Diamond Light Source

Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.

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