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  1. Diamond Light Source
  2. News and Literature
  3. Annual Review
  4. Diamond Annual Review 2019
  5. Science Group Updates
  6. Imaging and Microscopy Group

Imaging and Microscopy Group

  • annual review
    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist

    Sweet Success: Crystal structure of the full-length GLP-1 receptor bound to a peptide agonist Jun 1, 2018

    To design such small molecules, a detailed map of the interactions between GLP-1 and its receptor was needed.

  • annual review
    Structural insights into the mechanism of bacterial ABC transporters

    Structural insights into the mechanism of bacterial ABC transporters Jun 1, 2018

    Bacteria utilise ATP-binding cassette (ABC) transporters to import nutrients and detoxify themselves. These transporters have been shown to exist in wide open conformations that permit the access of many substrates in the binding pocket.

  • annual review
    Structure of the surface layer surrounding Caulobacter crescentus bacteria

    Structure of the surface layer surrounding Caulobacter crescentus bacteria Jun 1, 2018

    Many types of single-celled microorganisms such as bacteria are covered with a protective outer layer of proteins known as the S-layer.

  • annual review
    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint.

    How does an inspector call: structures of UGGT, the eukaryotic glycoprotein quality control checkpoint. Jun 1, 2018

    In all cells derived from animals, plants, fungi and protozoa a single protein called UGGT acts as a quality control checkpoint that inspects secreted glycoproteins.

  • annual review
    Insights into the mechanism of colistin resistance from crystal structures of MCR-1

    Insights into the mechanism of colistin resistance from crystal structures of MCR-1 Jun 1, 2018

    Gram-negative bacteria that are extensively resistant to multiple antibiotics are an ever-increasing global threat. Colistin is an antibiotic used as the last line of defence against highly resistant Gram-negative bacteria. However, in recent years bacteria have emerged with resistance to this crucial antibiotic.

  • annual review
    How human endoglin captures its ligand BMP9

    How human endoglin captures its ligand BMP9 Jun 1, 2018

    Endoglin (ENG)/CD105 is a mammalian glycoprotein that is found in the membranes of cells that line blood vessels. It is essential for healthy heart development and blood vessel growth, but conversely it is also involved in preeclampsia and can help tumours establish their blood supply.

Paul Quinn, Science Group Leader

The Imaging and Microscopy Group brings together eight experimental facilities (I08, J08, DIAD, I12, I13-1, I13-2, I14 and ePSIC) which use electrons and X-rays to image samples under different experimental conditions across a diverse range of length scales and time scales. Different contrast mechanisms allow for imaging of sample properties such as elemental composition, density and structure. This ability to extract image sample properties in minute detail lends itself to a wide range of scientific areas, from chemistry and catalysis to environmental science, materials science, biology, medicine and cultural heritage. Read more ...

  • annual review
    High-speed X-ray imaging reveals complex behaviour during metal 3D printing

    High-speed X-ray imaging reveals complex behaviour during metal 3D printing Aug 1, 2019

    A type of 3D printing called laser additive manufacturing (LAM) uses a high-energy laser beam to melt powder particles into a solid structure in under 1/1000th of a second. The powder melting process controls how materials are formed, governing the overall product performance. However, the fast laser-material interaction makes it difficult to optimise the processing conditions, resulting in defects. The presence of defects slows down the adoption of LAM for safety-critical engineering ...

  • annual review
    Discovering the nanoscale iron and calcium compounds that form in Alzheimer’s disease senile plaques

    Discovering the nanoscale iron and calcium compounds that form in Alzheimer’s disease senile plaques Aug 1, 2019

    Alzheimer’s disease is the most common form of dementia, yet its cause is unclear and there is no effective treatment. A hallmark of Alzheimer’s disease is the formation of amyloid plaques in the brain that disrupt its normal function. There is also an imbalance of metals, with increased levels of iron and harmful reactive iron forms being associated with amyloid plaques.

  • annual review
    Single atom catalysts boost efficiency and cut waste in fine chemical production

    Single atom catalysts boost efficiency and cut waste in fine chemical production Aug 1, 2019

    The chemical industry produces a tremendous amount of waste. Often this arises from the need to separate the product from a solution containing by-products and a dissolved catalyst. 85% of all industrial chemical processes use catalysts, chemicals that speed up a reaction but do not get used up in the process, and they are often expensive metals such as palladium.

  • annual review
    Maximising information from precious biological samples: Combining 3D X-ray imaging with traditional 2D histology

    Maximising information from precious biological samples: Combining 3D X-ray imaging with traditional 2D histology Aug 1, 2019

    C omplementary techniques that can maximise information derived from precious soft tissue samples are extremely valuable. A team from the Wolfson Centre for Age Related Diseases wanted to use 3D imaging to track how disease spreads through spinal tissue, followed by traditional 2D histology to probe the regions of interest identified in these scans at the molecular level. However, most 3D imaging methodologies require tissue preparation that prevents its subsequent use, or are too slow ...

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Diamond Light Source

Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.

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