Eilis Bragginton

Éilís obtained her PhD from the University of Bristol where she used X-ray crystallography to study the structure and mechanism of antibiotic degrading enzymes. She subsequently moved to the University of Birmingham as a research fellow, using cryo-EM and X-ray crystallography to characterise the structure and function of chromatin binding proteins and signalling modifications to proteins involved in the repair of damaged DNA.

Éilís joined eBIC in August 2022 as a Post-Doctoral Research Associate with Karen Davies, using cryo-EM and helical processing to investigate the structure of bacteriophage-like particles. In September 2023, Éilís became an Electron Microscope Scientist at eBIC. She has experience in SPA, tomography and also contributes to the cryoFIB user programme. As well as managing Krios I, she supports the waffle method for cryoFIB and microED at eBIC.

Éilís’ research interests centre on antimicrobial resistance, with a focus on how microbes evade treatment and alternative antimicrobial therapies. She utilises a range of cryo-EM techniques, including single particle, helical analysis and tomography of FIB-milled microbial films.

Hall, S. C. L. Hardy, D. J. Bragginton, É.C. Johnston, H. Onose, T. Holyfield, R. Sridhar, P.  Knowles, T. J. Clifton, L. A. (2024) Distance tuneable integral membrane protein containing floating bilayers via in situ directed self-assembly. Nanoscale, 16 13503-12515. DOI: 10.1039/D3NR04622B.

Torres Esteban, M. Stewart, M.J. Bragginton, E. Meroni, A. Pellizzari, A. Jeanrenaud, A. Smerdon, S. J. Stucki, M. (2025) MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks. Life Sci. Alliance, 8(5). DOI: 10.26508/lsa.202403074.

Samphire, J. Takebayashi, Y. Hill, S.A. Hill, N. Heesom, K.J. Lewis, P.A. Alibhai, D. Bragginton, E.C. Dorh, J. Dorh, N. Spencer, J. Carmen Galan, M. (2021) Green Fluorescent Carbon Dots as Targeting Probes for LED-Dependent Bacterial Killing. Nano Select, (2021). DOI: 10.1002/nano.202100183.

Azmi, L. Bragginton, E.C. Cadby, I. T. Byron, O. Roe, A. J. Lovering, A. L. Gabrielsen, M. (2020) High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE. Acta Crystallogr F Struct Biol Commun, 76(9):414-421. DOI: 10.1107/S2053230X20010237.

Tooke, C.L. Hinchliffe, P. Bragginton, E.C. Colenso, C. K. Hirvonen, V. H. Takebayashi, Y. Spencer, J. (2019) β- Lactamases and β-Lactamase inhibitors in the 21st Century. Journal of Molecular Biology, 431(18):3472-3500. DOI: 10.1016/j.jmb.2019.04.002.

Hall, S.C.L. Tognoloni, C. Charlton, J. Bragginton, É.C. Rothnie, A.J. Sridhar, P. Wheatley, M. Knowles, T. J. Edler, K. J. Arnold, T & Dafforn, T. R. (2018) An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles. Nanoscale, 10(22):10609-10619. DOI: 10.1039/C8NR01322E.

Bragginton, E.C. & Piddock, L.J. (2014) UK and European Union public and charitable funding from 2008 to 2013 for bacteriology and antibiotic research in the UK: an observational study. Lancet Infectious Disease, 14(9):857-868. DOI: 10.1016/S1473-3099(14)70825-4.