Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex Adam S. B. Jalal, Paul Girvan, Eugene Y. D. Chua, Lexin Liu, Shijie Wang, Elizabeth A. Mccormack, Michael T. Skehan, Carol L. Knight, David S. Rueda, Dale B. Wigley
Molecular Cell, 12 Sept 2024 DOI: 10.1016/j.molcel.2024.08.015 Cryo-EM structure of the CDK2-cyclin A-CDC25A complex Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Nature Communications, 15 Aug 2024 DOI: 10.1038/s41467-024-51135-w Bidirectional pilus processing in the Tad pilus system motor CpaF Michael Hohl, Emma J. Banks, Max P. Manley, Tung B. K. Le, Harry H. Low
Nature Communications, 15 Aug 2024 DOI: 10.1038/s41467-024-50280-6 Structural insights into Frizzled3 through nanobody modulators James Hillier, Yuguang Zhao, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Tao-Hsin Chang, Gangshun Yi, Helen M. E. Duyvesteyn, Jing Yu, Weixian Lu, Els Pardon, Jan Steyaert, Yanan Zhu, Tao Ni, E. Yvonne Jones
Nature Communications, 15 Aug 2024 DOI: 10.1038/s41467-024-51451-1 Journal Paper I03-Macromolecular Crystallography Krios II-Titan Krios II at Diamond open access Structural and biochemical insights into the mechanism of action of the clinical USP1 inhibitor, KSQ-4279 Martin L. Rennie, Mehmet Gundogdu, Connor Arkinson, Steven Liness, Sheelagh Frame, Helen Walden
Journal Of Medicinal Chemistry, Aug 2024 DOI: 10.1021/acs.jmedchem.4c01184 Structure of the bacteriophage PhiKZ non-virion RNA polymerase transcribing from its promoter p119L Natalia De Martin Garrido, Chao-Sheng Chen, Kailash Ramlaul, Christopher H. S. Aylett, Maria Yakunina
Journal Of Molecular Biology, 15 Jul 2024 DOI: 10.1016/j.jmb.2024.168713 Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs Gangshun Yi, Mingda Ye, Loic Carrique, Afaf H. El-Sagheer, Tom Brown, Chris J. Norbury, Peijun Zhang, Robert J. C. Gilbert
Nature Structural & Molecular Biology, 20 Jul 2024 DOI: 10.1038/s41594-024-01357-9 CryoET reveals actin filaments within platelet microtubules Chisato Tsuji, Marston Bradshaw, Megan F. Allen, Molly L. Jackson, Judith Mantell, Ufuk Borucu, Alastair W. Poole, Paul Verkade, Ingeborg Hers, Danielle M. Paul, Mark P. Dodding
Nature Communications, 15 Jul 2024 DOI: 10.1038/s41467-024-50424-8 FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions Pablo Alcon, Artur P. Kaczmarczyk, Korak Kumar Ray, Themistoklis Liolios, Guillaume Guilbaud, Tamara Sijacki, Yichao Shen, Stephen H. Mclaughlin, Julian E. Sale, Puck Knipscheer, David S. Rueda, Lori A. Passmore
Nature, 90 Jul 2024 DOI: 10.1038/s41586-024-07770-w Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Cryo-tomography and 3D electron diffraction reveal the polar habit and chiral structure of the malaria pigment crystal hemozoin Paul B. Klar, David G. Waterman, Tim Gruene, Debakshi Mullick, Yun Song, James B. Gilchrist, C. David Owen, Wen Wen, Idan Biran, Lothar Houben, Neta Regev-Rudzki, Ron Dzikowski, Noa Marom, Lukas Palatinus, Peijun Zhang, Leslie Leiserowitz, Michael Elbaum
Acs Central Science, Jul 2024 DOI: 10.1021/acscentsci.4c00162 A first peek at a "crass" virus Diamond Light Source
Jul 2024 Science Highlight Krios I-Titan Krios I at Diamond
CryoEM reveals the structure of an archaeal pilus involved in twitching motility Matthew C. Gaines, Shamphavi Sivabalasarma, Michail N. Isupov, Risat U. I. Haque, Mathew Mclaren, Cyril Hanus, Vicki A. M. Gold, Sonja-Verena Albers, Bertram Daum
Nature Communications, 15 June 2024 DOI: 10.1038/s41467-024-45831-w Distance tuneable integral membrane protein containing floating bilayers via in situ directed self-assembly Stephen C. L. Hall, David J. Hardy, Eilis C. Bragginton, Hannah Johnston, Tudor Onose, Rachel Holyfield, Pooja Sridhar, Timothy J. Knowles, Luke A. Clifton
Nanoscale, 277 June 2024 DOI: 10.1039/D3NR04622B Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria Alexander T. Bakker, Ioli Kotsogianni, Mariana Avalos, Jeroen M. Punt, Bing Liu, Diana Piermarini, Berend Gagestein, Cornelis J. Slingerland, Le Zhang, Joost J. Willemse, Leela B. Ghimire, Richard J. H. B. N. Van Den Berg, Antonius P. A. Janssen, Tom H. M. Ottenhoff, Constant A. A. Van Boeckel, Gilles P. Van Wezel, Dmitry Ghilarov, Nathaniel I. Martin, Mario Van Der Stelt
Nature Chemistry, 399 June 2024 DOI: 10.1038/s41557-024-01516-x Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I Daniel N. Grba, John J. Wright, Zhan Yin, William Fisher, Judy Hirst
Science, 384 June 2024 DOI: 10.1126/science.ado2075 Molecular basis for transposase activation by a dedicated AAA+ ATPase Álvaro De La Gándara, Mercedes Spínola-Amilibia, Lidia Araujo-Bazan, Rafael Nunez-Ramirez, James M. Berger, Ernesto Arias-Palomo
Nature, 630 June 2024 DOI: 10.1038/s41586-024-07550-6 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Development of focused ultrasound-assisted nanoplexes for RNA delivery Sanjeev Ranjan, Stef Bosch, Hannamari Lukkari, Johanna Schirmer, Niina Aaltonen, Heikki J. Nieminen, Vesa-Pekka Lehto, Arto Urtti, Tatu Lajunen, Kirsi Rilla
Nanomaterials, 14 June 2024 DOI: 10.3390/nano14131089 Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Roedstroem, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Nature Communications, 15 June 2024 DOI: 10.1038/s41467-024-48921-x Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist Gamma Chi, Dawid Jaślan, Veronika Kudrina, Julia Böck, Huanyu Li, Ashley C. W. Pike, Susanne Rautenberg, Einar Krogsaeter, Tina Bohstedt, Dong Wang, Gavin Mckinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Marco Keller, Franz Bracher, Christian Grimm, Katharina L. Dürr
Structure, 594 May 2024 DOI: 10.1016/j.str.2024.05.005 Understanding a protein that fuels bowel cancer Diamond Light Source
May 2024 Science Highlight Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond
EMinsight : a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition Daniel Hatton, Jaehoon Cha, Stephen Riggs, Peter Harrison, Jeyan Thiyagalingam, Daniel K. Clare, Kyle L. Morris
Acta Crystallographica Section D Structural Biology, 80 Apr 2024 DOI: 10.1107/S2059798324001578 Journal Paper Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond open access Conformational changes in the Niemann–Pick type C1 protein NCR1 drive sterol translocation Kelly M. Frain, Emil Dedic, Lynette Nel, Anastasiia Bohush, Esben Olesen, Katja Thaysen, Daniel Wüstner, David L. Stokes, Bjorn Panyella Pedersen
Proceedings Of The National Academy Of Sciences, 121 Apr 2024 DOI: 10.1073/pnas.2315575121 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter Josep Rullo-Tubau, Maria Martinez-Molledo, Paola Bartoccioni, Ignasi Puch-Giner, Ángela Arias, Suwipa Saen-Oon, Camille Stephan-Otto Attolini, Rafael Artuch, Lucía Díaz, Víctor Guallar, Ekaitz Errasti-Murugarren, Manuel Palacin, Oscar Llorca
Nature Communications, 15 Apr 2024 DOI: 10.1038/s41467-024-47385-3 The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili Dawid S. Zyla, Thomas Wiegand, Paul Bachmann, Rafal Zdanowicz, Christoph Giese, Beat H. Meier, Gabriel Waksman, Manuela K. Hospenthal, Rudi Glockshuber
Nature Communications, 15 Apr 2024 DOI: 10.1038/s41467-024-47212-9 Journal Paper Krios I-Titan Krios I at Diamond Krios IV-Titan Krios IV at Diamond open access Architecture and regulation of filamentous human cystathionine beta-synthase Thomas J. Mccorvie, Douglas Adamoski, Raquel A. C. Machado, Jiazhi Tang, Henry J. Bailey, Douglas S. M. Ferreira, Claire Strain-Damerell, Arnaud Basle, Andre L. B. Ambrosio, Sandra M. G. Dias, Wyatt W. Yue
Nature Communications, 15 Apr 2024 DOI: 10.1038/s41467-024-46864-x Structural basis for the modulation of MRP2 activity by phosphorylation and drugs Tiziano Mazza, Theodoros I. Roumeliotis, Elena Garitta, David Drew, S. Tamir Rashid, Cesare Indiveri, Jyoti S. Choudhary, Kenneth J. Linton, Konstantinos Beis
Nature Communications, 15 Mar 2024 DOI: 10.1038/s41467-024-46392-8 A service-based approach to cryoEM facility processing pipelines at eBIC Anna Horstmann, Stephen Riggs, Yuriy Chaban, Daniel K. Clare, Guilherme De Freitas, David Farmer, Andrew Howe, Kyle L. Morris, Daniel Hatton
Acta Crystallographica Section D Structural Biology, 80 Mar 2024 DOI: 10.1107/S2059798324000986 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond Krios III-Titan Krios III at Diamond Krios IV-Titan Krios IV at Diamond Krios V-Titan Krios V at Diamond open access A structural and dynamic visualization of the interaction between MAP7 and microtubules Agnes Adler, Mamata Bangera, J. Wouter Beugelink, Salima Bahri, Hugo Van Ingen, Carolyn A. Moores, Marc Baldus
Nature Communications, 15 Mar 2024 DOI: 10.1038/s41467-024-46260-5 Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Nature Communications, 15 Mar 2024 DOI: 10.1038/s41467-024-46235-6 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access The binding and mechanism of a positive allosteric modulator of Kv3 channels Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin J. Gunthorpe, Giuseppe Alvaro, Charles H. Large, David B. Sauer, Werner Treptow, Manuel Covarrubias
Nature Communications, 15 Mar 2024 DOI: 10.1038/s41467-024-46813-8 Journal Paper Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access Expression, purification, and Cryo-EM structural analysis of an outer membrane secretin channel Rebecca Conners, Mathew Mclaren, Marjorie Russel, Vicki A. M. Gold
Mar 2024 DOI: 10.1007/978-1-0716-3734-0_18 Filament structure and subcellular organization of the bacterial intermediate filament–like protein crescentin Yue Liu, Fusinita Van Den Ent, Jan Lowe
Proceedings Of The National Academy Of Sciences, 121 Feb 2024 DOI: 10.1073/pnas.2309984121 Structure of the plant plastid-encoded RNA polymerase Ángel Vergara-Cruces, Ishika Pramanick, David Pearce, Vinod K. Vogirala, Matthew J. Byrne, Jason K. K. Low, Michael W. Webster
Cell, 187 Feb 2024 DOI: 10.1016/j.cell.2024.01.036 Journal Paper Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Understanding the power of movement in plants Diamond Light Source
Feb 2024 Science Highlight Krios II-Titan Krios II at Diamond
A new family of bacterial ribosome hibernation factors Karla Helena-Bueno, Mariia Yu. Rybak, Chinenye L. Ekemezie, Rudi Sullivan, Charlotte R. Brown, Charlotte Dingwall, Arnaud Basle, Claudia Schneider, James P. R. Connolly, James N. Blaza, Bálint Csörgő, Patrick J. Moynihan, Matthieu G. Gagnon, Chris H. Hill, Sergey V. Melnikov
Nature, 52 Feb 2024 DOI: 10.1038/s41586-024-07041-8 Structural basis of σ54 displacement and promoter escape in bacterial transcription Forson Gao, Fuzhou Ye, Bowen Zhang, Nora Cronin, Martin Buck, Xiaodong Zhang
Proceedings Of The National Academy Of Sciences, 121 Jan 2024 DOI: 10.1073/pnas.2309670120 Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4−/− mouse Zhan Yin, Ahmed-Noor A. Agip, Hannah R. Bridges, Judy Hirst
The Embo Journal, 1861 Jan 2024 DOI: 10.1038/s44318-023-00001-4 Journal Paper Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond open access 
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