Cotadutide reversible self-assembly based long-acting injectable depot for sustained delivery of GLP-1 glucagon receptor agonists with controlled burst release Bin Yang, Durga Devalla, Silvia Sonzini, Mikael Boberg, Sashi Gopaul, Monika Sundqvist, Iain Grant, Christopher Jones, Stephanie Brookes, Cindy Weidauer, Eleonora Paladino, Najet Mahmoudi, Jason Van Rooyen, Ana Gomes Dos Santos, Johanna Laru, Andy Campbell, Lutz Jermutus, Annette Bak
Journal Of Controlled Release, 380 Apr 2025 DOI: 10.1016/j.jconrel.2025.01.064 PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia E. Angelova, Karoline Wenzl, Andreas Brandstätter, Jiri Veis, Fran Miočić-Stošić, Dorothea Anrather, Markus Hartl, Linda Truebestein, Luis M. Cerron-Alvan, Martin Leeb, Bojan Žagrović, Stephan Hann, Christoph Bock, Egon Ogris, Todor Dudev, Nicholas A. T. Irwin, David Haselbach, Thomas A. Leonard
Proceedings Of The National Academy Of Sciences, 122 Apr 2025 DOI: 10.1073/pnas.2417218122 Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment Zhuoyao Chen, Gamma Chi, Timea Balo, Xiangrong Chen, Beatriz Ralsi Montes, Steven C. Clifford, Vincenzo D'Angiolella, Timea Szabo, Arpad Kiss, Tibor Novak, András Herner, András Kotschy, Alex N. Bullock
Nature Communications, 16 Apr 2025 DOI: 10.1038/s41467-025-58350-z Journal Paper Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213 Katerina Naydenova, Keith B. Boyle, Claudio Pathe, Prathyush Pothukuchi, Ana Crespillo-Casado, Felix Scharte, Pierre-Mehdi Hammoudi, Elsje G. Otten, Neal M. Alto, Felix Randow
Nature Structural & Molecular Biology, 62 Apr 2025 DOI: 10.1038/s41594-025-01530-8 Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase Manikandan Karuppasamy, Jason Van Rooyen
Acta Crystallographica Section F Structural Biology Communications, 81 Mar 2025 DOI: 10.1107/S2053230X25001098 Cryo-EM structures of a protein pore reveal a cluster of cholesterol molecules and diverse roles of membrane lipids Gasper Solinc, Marija Srnko, Franci Merzel, Ana Crnković, Mirijam Kozorog, Marjetka Podobnik, Gregor Anderluh
Nature Communications, 16 Mar 2025 DOI: 10.1038/s41467-025-58334-z Structure and regulatory mechanism of human uncoupling protein 1 Scott Jones
Mar 2025 DOI: 10.17863/CAM.116448 Thesis Krios I-Titan Krios I at Diamond Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland Gabriel Magno De Freitas Almeida, Iker Arriaga, Bruna Luiza De Azevedo, Miika Leppänen, Jonatas S. Abrahão, Julien Andreani, Davide Zabeo, Janne J. Ravantti, Nicola G. A. Abrescia, Lotta-Riina Sundberg
Elife, 13 Mar 2025 DOI: 10.7554/eLife.103492 Journal Paper Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Penton blooming, a conserved mechanism of genome delivery used by disparate microviruses Pavol Bardy, Conor I. W. Macdonald, Paul C. Kirchberger, Huw T. Jenkins, Tibor Botka, Lewis Byrom, Nawshin T. B. Alim, Daouda A. K. Traore, Hannah C. Koenig, Tristan R. Nicholas, Maria Chechik, Samuel J. Hart, Johan P. Turkenburg, James N. Blaza, J. Thomas Beatty, Paul C. M. Fogg, Alfred A. Antson
Mbio, Mar 2025 DOI: 10.1128/mbio.03713-24 Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation Lee Sherry, Keith Grehan, Mohammad W. Bahar, Jessica J. Swanson, Helen Fox, Sue Matthews, Sarah Carlyle, Ling Qin, Claudine Porta, Steven Wilkinson, Suzanne Robb, Naomi Clark, John Liddell, Elizabeth E. Fry, David I. Stuart, Andrew J. Macadam, David J. Rowlands, Nicola J. Stonehouse
Npj Vaccines, 10 Mar 2025 DOI: 10.1038/s41541-025-01111-2 Stepwise recruitment of chaperone Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibril disassembly Jim Monistrol, Joseph G. Beton, Erin C. Johnston, Thi Lieu Dang, Bernd Bukau, Helen R. Saibil
Communications Biology, 8 Mar 2025 DOI: 10.1038/s42003-025-07906-2 Molecular mechanism of bacteriophage contraction structure of an S-layer–penetrating bacteriophage Jason S. Wilson, Louis-Charles Fortier, Robert P Fagan, Per A. Bullough
Life Science Alliance, 8 Mar 2025 DOI: 10.26508/lsa.202403088 The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP Alberto Palacios-Abella, Andres Lopez-Perrote, Jasminka Boskovic, Sandra Fonseca, Cristina Úrbez, Vicente Rubio, Oscar Llorca, David Alabadí
Structure, 18 Feb 2025 DOI: 10.1016/j.str.2025.01.023 Proton conductance by human uncoupling protein 1 is inhibited by purine and pyrimidine nucleotides Scott A. Jones, Alice P. Sowton, Denis Lacabanne, Martin S. King, Shane M. Palmer, Thomas Zogg, Els Pardon, Jan Steyaert, Jonathan J. Ruprecht, Edmund R. S. Kunji
The Embo Journal, 630 Feb 2025 DOI: 10.1038/s44318-025-00395-3 Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55 Tobias Claff, Rebecca Ebenhoch, Jörg T. Kley, Aniket Magarkar, Herbert Nar, Dietmar Weichert
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-57204-y Jigsaw puzzle: Deciphering the chloroplast transcription machinery Diamond Light Source
Jan 2025 Science Highlight Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 Huanyu Z. Li, Ashley C. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin Mckinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Duerr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer
Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-55942-7 Journal Paper Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse, David J. Rowlands
Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56118-z Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. Mcmahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith
Open Biology, 15 Jan 2025 DOI: 10.1098/rsob.240310 Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography Krios II-Titan Krios II at Diamond open access Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT Chloe Seddon, Sophia David, Joshua L. C. Wong, Naito Ishimoto, Shan He, Jonathan Bradshaw, Wen Wen Low, Gad Frankel, Konstantinos Beis
Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-55834-w Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament Emmajay Sutherland, Christopher J. Harding, Tancrède Du Monceau De Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster
Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56127-y The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Anokhi Shah, Xiaoli Zhang, Matthew Snee, Michael P. Lockhart-Cairns, Colin W. Levy, Thomas A. Jowitt, Holly L. Birchenough, Louisa Dean, Richard Collins, Rebecca J. Dodd, Abigail R. E. Roberts, Jan J. Enghild, Alberto Mantovani, Juan Fontana, Clair Baldock, Antonio Inforzato, Ralf P. Richter, Anthony J. Day
Matrix Biology, 57 Jan 2025 DOI: 10.1016/j.matbio.2025.01.002 Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) Krios IV-Titan Krios IV at Diamond open access 
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