MX Responsive Beamtime Guide

These dates are for both interactive visits and Unattended Data Collection (UDC).

• Remote, Interactive Access for MX
• Onsite Experiments on all MX beamlines and facilities
• Serial Crystallography experiments on I24 - though these may be scheduled long in advance
• Automated - Unattended Data Collection
• Long-wavelength experiments on I23 - contact PBS Armin Wagner
• In-situ data collection on VMXi - discuss with the beamline team 
• Crystallisation Facility in the Research Complex at Harwell
• Micro/nano-focus samples on VMXm - discuss with the beamline team

For a full range of propietory access, including utilising the team for mail-in services, discuss with the Industrial Liaison Office.

The following experiments are conducted within MX beamlines or facilities, but need longer-term scheduling due to the complexity of experiments:

• Fragment Screening with XChem
• Membrane Protein Laboratory
• B21 sessions, if part of an MX BAG

In addition, Serial Crystallography experiments are frequently scheduled a long time in advance.

During Diamond's 5 Run periods per year, the synchrotron provides User Beam 6 days per week with most Tuesdays as Machine Days for maintenance of the synchrotron ring. Therefore User Beam is available between 9:00 on Wednesdays through to 9:00 on Tuesdays.

On-site visits are also possible again, and we are keen to welcome Users - particularly to enhance the training of early-career crystallographers.

Scheduling can be done:

• Responsively - a suitable time is scheduled after the dewar has arrived on site, taking into account the parameters requested for that shipment
• Pre-Scheduled - Users can pre-book sessions with mx-usersupport@diamond.ac.uk at least 2 weeks in advance (particularly for on-site visits), to support training, aid logistics, liaise with Diamond staff or any other reason
• Unattended Data Collection (UDC) - does not require scheduling as samples join a queue and get their data collection as soon as possible.
• By liaison with our specialised beamlines such as I23, VMXi, VMXm and the Crystallisation Facility.

All users requiring training or information should get in touch with the local contact associated with their visit. Please write to mx-usersupport@diamond.ac.uk if no local contact has been assigned, for instance, if the visit has not been scheduled yet. 

Industrial users (proprietary access) should liaise with industry@diamond.ac.uk.

A dewar must only contain samples for UDC or for Interactive sessions - we cannot accept dewars with samples for mixed experiment types. A shipment in ISPyB should also only contain one experiment type - but you can create multiple shipments in ISPyB which can all be collected at the same time.

We now schedule by the hour for remote access and mail-in sessions based on the information provided by yourselves at the shipment stage. Samples for responsive remote access will be scheduled once they are on-site, and have information completed on samples in ISPyB. Where feasible we may be able to make slots available the same week and we will contact you to set these up. Equally if demand is high at any time we may need to contact you to allocate the earliest available slot outside of the period you have provided with your shipment for your availability. 

Scheduled users will receive notification of time automatically from UAS. Please contact us immediately if there are any issues with the allocated time. We will have limited opportunities to adjust the schedule and your time may need to be deferred to a later slot if you cannot use the offered time.

Samples for automated unattended data collection will be collected at the earliest possible available slot.

Scheduling for on site, or supported remote session will be done in advance, by contacting mx-usersupport@diamond.ac.uk and the relevant Principle Beamline Scientist. This may be in advance of the samples sent to Diamond, in this case you should send samples to against that registered visit. 

For all routes, we need all container and sample information completed before shipment to Diamond. 

On site visits can be booked in advance (normally at least 2 weeks) for Users to collect their data onsite at one of our beamlines. One reason to do this may be for the training of early-career crystallographers to get more immersed in the workings of the synchrotron and it's beamlines, and in addition to the data collection visit itself, we may be able to offer the opportunity to see additional facilities or meet members of the Diamond team. 

Diamond-staff supported visits can also be booked in advance - whether for on-site support together in the beamline control room, or online support for a remote session, for instance delivered via Zoom. This is needed where support is needed beyond what might be expected of a Local Contact. A supported remote session may have involvement of a staff member on your session, perhaps for a challenging phasing problem, training new staff or students, or for testing new features of the beamlines. 

To request either on site access, or a supported remote session please get in touch with the relevant Principal Beamline Scientist and mx-usersupport@diamond.ac.uk more than 2 weeks before the session is required and we will confirm whether the request is feasible. If you're request could be dealt with by multiple beamlines, then email mx-usersupport@diamond.ac.uk in the first instance and we can forward to the most appropriate Principle Beamline Scientist.

Automated unattended data collection (academic/industrial)

If you have a crystal system that meets straightforward requirements then the automated unattended data collection service is for you.

• Single crystal >15 µm in size
• Ability to set a target resolution, either through prior knowledge or experimental requirements

You simply provide us with some limited information when creating your shipment and samples in ISPyB and we handle the rest, with data collected as soon as reasonably possible. This is the most flexible way for us to schedule beamtime currently and places no constraints on your time to be available for collection. More instructions can be found on the Unattended Data Collection pages.

Remote interactive data collection

Standard (responsive) remote access to all beamlines. If you have a challenging problem (for example, new crystals to test where diffraction quality is unknown, difficult phasing problems or require microfocus beam) then an interactive remote access visit is likely appropriate. For these visits we will schedule your visit once we have received your samples at Diamond. 

Full information about how to ship your samples can be found on the Shipping Samples page.

Please ensure:

• All samples must have been added to your proposal in UAS and been approved by Diamond SHE prior to shipping - do this well in advance of wanting to send samples to allow time for review and approval by Diamond.
• All samples must be shipped to site by recognised couriers to be delivered to ours Goods-In department. Alternatively email mx-usersupport@diamond.ac.uk if you wish to deliver them to our Goods-In department. 
• A Dewar must only contain samples for UDC or responsive remote session or mail-in currently. We cannot accept Dewars with samples for mixed experiment types. A shipment should also only contain one experiment type. 
• Sample mounts and shipments for I23 beamtime should be coordinated with Armin Wagner.

For enquiries (except for I23, VMXi and industry) prior to any beamtime please contact mx-usersupport@diamond.ac.uk who will coordinate a response to your questions. 

• For I23 queries please liaise with Armin Wagner (armin.wagner@diamond.ac.uk).
• For VMXi please contact via VMXI@diamond.ac.uk. 
• For industry queries please liaise with industry@diamond.ac.uk.

Once a visit has been scheduled and a local contact has been assigned please liaise with them first (see UAS for your local contact).