Leeds 3D (Decommissioned)

This library was designed by the Nelson and Marsden groups (University of Leeds) to allow the efficient exploration of chemical space. Fragments in this library have the following features:

• Diverse, natural product-like scaffolds.
• 3-Dimensional shapes.
• High sp3 content.
• Suitable functional handles to enable synthetic elaboration of hits.

These fragments were prepared by a concise 'top down' synthetic approach (see references below) and have proven to be productive in the identification of distinctive hits at Diamond.

Compounds:

• 125 fragments
• d6-DMSO

SMILES: click to download the Leeds 3D SMILES

For follow-ups, please contact: N/A

PUBLICATION to cite:

"Realisation of small molecule libraries based on frameworks distantly related to natural products" A. Aimon, G. Karageorgis, J. Masters, M. Dow, P. G. E. Craven, M. Ohsten, A. Willaume, R. Morgentin, N. R. -L., H. Lemoine, T. Kalliokoski, A. J. Eatherton, D. J. Foley, S. P. Marsden and A. Nelson, Org. Biomol. Chem. 2018, 16, 3160-3167 (link)

"Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks" D. J. Foley, P. G. E. Craven, P. M. Collins, R. G. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. P. Marsden, A. Nelson, Chem. Eur. J. 2017, 23, 15227-15232 (pdf)