These publications are based on data gathered on beamline I04-1. If you are aware of any errors or publications that should be listed here, please send details to publications@diamond.ac.uk.
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity Meng Wang, Prasanthi Medarametla, Thales Kronenberger, Tomas Deingruber, Paul Brear, Wendy Figueroa, Pok-Man Ho, Thomas Krueger, James C. Pearce, Antti Poso, James G. Wakefield, David R. Spring, Martin Welch
Nature Communications, 16 Mar 2025 DOI: 10.1038/s41467-025-57532-z Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore Shawn C. Massoni, Nicola J. Evans, Ingo Hantke, Colleen Fenton, James H. Torpey, Katherine M. Collins, Ewelina M. Krysztofinska, Janina H. Muench, Arjun Thapaliya, Santiago Martínez-Lumbreras, Sé Hart Ferrell, Celia Slater, Xinyue Wang, Ruth Fekade, Sandra Obwar, Siyu Yin, Alishba Vazquez, Christopher B. Prior, Kürşad Turgay, Rivka L. Isaacson, Amy H. Camp
Genes & Development, Mar 2025 DOI: 10.1101/gad.352498.124 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS Avinash V. Dharmadhikari, Maria Alba Abad, Sheraz Khan, Reza Maroofian, Tristan T. Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A. Wear, Kiara E. Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K. Lee, Christine H. Umandap, Sara M. Berger, Alejandro D. Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L. Rippert, Christopher Gray, Kosuke Izumi, Laura K. Conlin, Daniel C. Koboldt, Theresa Mihalic Mosher, Scott E. Hickey, Dara V. F. Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E. Posey, Natalie C. Lippa, Natalie Vena, Erin L. Heinzen, David B. Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S. Zaki, Ghada M. H. Abdel-Salam, Mohamed S. Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C. Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N. Wontakal, Vimla S. Aggarwal, Jill A. Rosenfeld, Victor Tarabykin, Shinya Ohta, James R. Lupski, Henry Houlden, William C. Earnshaw, Erica E. Davis, A. Arockia Jeyaprakash, Jun Liao
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56876-w Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access Molecular analysis of carbohydrate recognition by Collectin-10 and Collectin-11 Alanoud F. Alrehaili
Feb 2025 Thesis I04-1-Macromolecular Crystallography (fixed wavelength)
Structures of the cyanobacterial nitrogen regulators NtcA and PipX complexed to DNA shed light on DNA binding by NtcA and implicate PipX in the recruitment of RNA polymerase Alicia Forcada-Nadal, Sirine Bibak, Paloma Salinas, Asunción Contreras, Vicente Rubio, Jose L. Llacer
Nucleic Acids Research, 53 Feb 2025 DOI: 10.1093/nar/gkaf096 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) open access Binding‐site purification of actives (B‐SPA) enables efficient large‐scale progression of fragment hits by combining multi‐step array synthesis with HT crystallography Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbe Koekemoer, James Bennett, Anthony Bradley, Cameron Anderson, Conor Wild, William J. Bradshaw, Edward A. Fitzgerald, Tobias Krojer, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank Von Delft
Angewandte Chemie International Edition, Feb 2025 DOI: 10.1002/anie.202424373 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) Crystal structure of Anopheles gambiae actin depolymerizing factor explains high affinity to monomeric actin Devaki Lasiwa, Inari Kursula
The Febs Journal, 54 Feb 2025 DOI: 10.1111/febs.70007 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) Structure and activity of a phosphinothricin N-acetyltransferase (PSPTO_3321) from Pseudomonas syringae pv. tomato DC3000 Anna M. Davies, David Trentham, Brian J. Sutton, Paul R. Brown
Biochemical And Biophysical Research Communications, 6 Feb 2025 DOI: 10.1016/j.bbrc.2025.151539 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy Joseph A Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert Te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, Carrow I. Wells, Zachary W. Davis-Gilbert, Paul Workman, Opher Gileadi, David H. Drewry
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56213-1 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks K.-Y. M. Chen, J. K. Lai, L. S. P. Rudden, J. Wang, A. M. Russell, K. Conners, M. E. Rutter, B. Condon, F. Tung, L. Kodandapani, B. Chau, X. Zhao, J. Benach, K. Baker, E. J. Hembre, P. Barth
Nature Chemistry, 166 Jan 2025 DOI: 10.1038/s41557-024-01719-2 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) open access KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid Thomas C. Mclean, Francisco Balaguer-Pérez, Joshua Chandanani, Christopher M. Thomas, Clara Aicart-Ramos, Sophia Burick, Paul Dominic B. Olinares, Giulia Gobbato, Julia E. A. Mundy, Brian T. Chait, David M. Lawson, Seth A. Darst, Elizabeth A. Campbell, Fernando Moreno-Herrero, Tung Le
Nature Microbiology, 20 Jan 2025 DOI: 10.1038/s41564-024-01915-3 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access Molecular basis of human angiotensin‐1 converting enzyme inhibition by a series of diprolyl‐derived compounds Kyle S. Gregory, Gyles E. Cozier, Stephen Fienberg, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya
The Febs Journal, 389 Jan 2025 DOI: 10.1111/febs.17384 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel CRBN-binding agents in myeloma Yakinthi Chrisochoidou, Andrea Scarpino, Salomon Morales, Shannon Martin, Sarah A. Bird, Yigen Li, Brian A. Walker, John Caldwell, Yann-Vai Le Bihan, Charlotte Pawlyn
Blood Journal, Jan 2025 DOI: 10.1182/blood.2024025861 Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Anokhi Shah, Xiaoli Zhang, Matthew Snee, Michael P. Lockhart-Cairns, Colin W. Levy, Thomas A. Jowitt, Holly L. Birchenough, Louisa Dean, Richard Collins, Rebecca J. Dodd, Abigail R. E. Roberts, Jan J. Enghild, Alberto Mantovani, Juan Fontana, Clair Baldock, Antonio Inforzato, Ralf P. Richter, Anthony J. Day
Matrix Biology, 57 Jan 2025 DOI: 10.1016/j.matbio.2025.01.002 Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) Krios IV-Titan Krios IV at Diamond open access Tearing down bacterial membranes with new antibiotics Diamond Light Source
Jan 2025 Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Macromolecular Crystallography
Macromolecular
Soft Condensed 
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Biological
Magnetic
Structures and
Crystallography 
Spectroscopy