These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to publications@diamond.ac.uk.
Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability Josh Mcquail, Miroslav Krepl, Kai Katsuya-Gaviria, Aline Tabib-Salazar, Lynn Burchell, Thorsten Bischler, Tom Gräfenhan, Paul Brear, Jiří Šponer, Ben F. Luisi, Sivaramesh Wigneshweraraj
Nucleic Acids Research, 53 Feb 2025 DOI: 10.1093/nar/gkaf019 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Investigation into the effect of phenylalanine gating on anaerobic haem breakdown using the energy landscape approach Alasdair D. Keith, Elizabeth B. Sawyer, Desmond C. Y. Choy, James L. Cole, Cheng Shang, George S. Biggs, Oskar J. Klein, Paul D. Brear, David J. Wales, Paul D. Barker
Protein Science, 34 Feb 2025 DOI: 10.1002/pro.5243 Discovery and optimization of pyrazine carboxamide AZ3246, a selective HPK1 inhibitor Jason D. Shields, David Baker, Amber Y. S. Balazs, Gayathri Bommakanti, Robert Casella, Shenggen Cao, Steve Cook, Randolph A. Escobar, Stephen Fawell, Francis D. Gibbons, Kathryn A. Giblin, Frederick W. Goldberg, Eric Gosselin, Tyler Grebe, Niresh Hariparsad, Holia Hatoum-Mokdad, Rachel Howells, Samantha J. Hughes, Anne Jackson, Iswarya Karapa Reddy, Jason G. Kettle, Gillian M. Lamont, Scott Lamont, Min Li, Sten O. Nilsson Lill, Deanna A. Mele, Anthony J. Metrano, Adelphe M. Mfuh, Lucas A. Morrill, Bo Peng, Alexander Pflug, Theresa A. Proia, Hadi Rezaei, Ryan Richards, Magdalena Richter, Kevin J. Robbins, Maryann San Martin, Marianne Schimpl, Alwin G. Schuller, Li Sha, Minhui Shen, James E. Sheppeck, Meha Singh, Stephen Stokes, Kun Song, Yuanyuan Sun, Haoran Tang, David J. Wagner, Jianyan Wang, Yanjun Wang, David M. Wilson, Allan Wu, Chengyan Wu, Dedong Wu, Ye Wu, Kevin Xu, Yue Yang, Tieguang Yao, Minwei Ye, Andrew X. Zhang, Hui Zhang, Xiang Zhai, Yanxiao Zhou, Robert E. Ziegler, Neil P. Grimster
Journal Of Medicinal Chemistry, Feb 2025 DOI: 10.1021/acs.jmedchem.4c02631 Confinement and catalysis within de novo designed peptide barrels Rokas Petrenas, Olivia A. Hawkins, Jacob F. Jones, D. Arne Scott, Jordan Fletcher, Ulrike Obst, Lucia Lombardi, Fabio Pirro, Graham J. Leggett, Thomas A. A. Oliver, Derek N. Woolfson
Journal Of The American Chemical Society, Jan 2025 DOI: 10.1021/jacs.4c16633 A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements Sophie E. Clough, Tessa R. Young, Emma Tarrant, Andrew J. P. Scott, Peter T. Chivers, Arthur Glasfeld, Nigel J. Robinson
Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56199-w Molecular basis of human angiotensin‐1 converting enzyme inhibition by a series of diprolyl‐derived compounds Kyle S. Gregory, Gyles E. Cozier, Stephen Fienberg, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya
The Febs Journal, 389 Jan 2025 DOI: 10.1111/febs.17384 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl Christopher P. Earl, Mathias Cobbaut, André Barros-Carvalho, Marina E. Ivanova, David C. Briggs, Eurico Morais-De-Sá, Peter J. Parker, Neil Q. Mcdonald
Nature Structural & Molecular Biology, 23 Jan 2025 DOI: 10.1038/s41594-024-01425-0 Highly optimized CNS penetrant inhibitors of EGFR Exon20 insertion mutations William Mccoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Cortés González, Sabina Cosulich, Nichola L. Davies, Nicolas Floc’h, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnström, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren Mckerrecher, Neville Mclean, J. Willem M. Nissink, Jonathan P. Orme, Paige Orwig, Martin J. Packer, Stuart Pearson, Lina Qin, Catarina Felisberto-Rodrigues, Adriana Savoca, Magnus Schou, Stephen Stokes, Aisha M. Swaih, Sara Talbot, Michael J. Tucker, Richard A. Ward, Emma Wadforth, Chunli Wang, Joanne Wilson, Yawen Yang
Journal Of Medicinal Chemistry, Jan 2025 DOI: 10.1021/acs.jmedchem.4c02811 Development of D-box peptides to inhibit the anaphase promoting complex/cyclosome Rohan Eapen, Cynthia Okoye, Christopher Stubbs, Marianne Schimpl, Thomas Tischer, Eileen Mccall, Maria Zacharopoulou, Fernando Ferrer, David Barford, David Spring, Cath Lindon, Christopher Phillips, Laura S. Itzhaki
Elife, Jan 2025 DOI: 10.7554/eLife.104238.1