Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: robin.owen@diamond.ac.uk
Science Group Leader
Dave Hall
Email: david.hall@diamond.ac.uk
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to publications@diamond.ac.uk.
23 items found for 2026 [total: 1232]
Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria Biomedicine & Pharmacotherapy, 199 June 2026 DOI: 10.1016/j.biopha.2026.119371
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Generation and modulation of catalytically relevant states of a dye-decolourizing peroxidase using time-resolved serial femtosecond crystallography with drop-on-chip mixing and X-ray-driven reduction Acta Crystallographica Section D Structural Biology, 82 May 2026 DOI: 10.1107/S2059798326001658
Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe 2+ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin Dalton Transactions, Apr 2026 DOI: 10.1039/D5DT02739J
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells Nature, 44 Apr 2026 DOI: 10.1038/s41586-026-10394-x
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Template technology for biocrystallization Apr 2026 DOI: 10.26174/thesis.lboro.32048493
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus
Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide Acta Crystallographica Section F Structural Biology Communications, 82 Apr 2026 DOI: 10.1107/S2053230X26001937
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Increasing X-ray energy improves data quality in serial crystallography Journal Of Synchrotron Radiation, 33 Mar 2026 DOI: 10.1107/S1600577525011063
Experience with the Jungfrau-1M detector at Diamond Light Source Journal Of Synchrotron Radiation, 33 Mar 2026 DOI: 10.1107/S1600577526000342
Evolutionarily divergent DUF4465 domains have a common vitamin B12 ‐binding function Febs Open Bio, 369 Mar 2026 DOI: 10.1002/2211-5463.70231
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P Journal Of Biological Chemistry, 387 Mar 2026 DOI: 10.1016/j.jbc.2026.111372
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
BtuJ1, a surface-exposed B12-binding protein in Bacteroidota, functions as an extracellular vitamin reservoir that enhances fitness Journal Of Molecular Biology, 375 Mar 2026 DOI: 10.1016/j.jmb.2026.169754
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure, function, and applications of two novel phage recombinases from extreme environments Nucleic Acids Research, 54 Feb 2026 DOI: 10.1093/nar/gkag069
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen Nature Communications, 17 Feb 2026 DOI: 10.1038/s41467-026-69572-0
Integrated structural dynamics uncover a new B12 photoreceptor activation mode Nature, 47 Feb 2026 DOI: 10.1038/s41586-025-10074-2
Journal Paper I24-Microfocus Macromolecular Crystallography
An enzyme's metal preference evolves through redox modulation driven by the cofactor’s secondary coordination sphere Molecular Biology And Evolution, Feb 2026 DOI: 10.1093/molbev/msag040
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification of ZFTA as a novel KLHL20 substrate and mechanistic insights into fuzzy binding of disordered peptides via biosensor analysis and computational modelling Chembiochem, 27 Feb 2026 DOI: 10.1002/cbic.70237
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase Nature Communications, 30 Feb 2026 DOI: 10.1038/s41467-026-69425-w
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-throughput ligand diversification to discover chemical inducers of proximity Nature Chemical Biology, 184 Feb 2026 DOI: 10.1038/s41589-025-02137-2
Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction Life Science Alliance, 9 Feb 2026 DOI: 10.26508/lsa.202503247
Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain Plos Pathogens, 22 Feb 2026 DOI: 10.1371/journal.ppat.1013926
A Hanks‐type bacterial kinase, PknS , directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation The Febs Journal, 9 Jan 2026 DOI: 10.1111/febs.70384
Multi-crystal X-ray diffraction (MCXRD) bridges the crystallographic characterisation gap in chemistry and materials science: application to MOFs Angewandte Chemie International Edition, 1 Jan 2026 DOI: 10.1002/anie.202523233
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus open access
The S180R human germline variant of DNA polymerase β Is a low fidelity enzyme with reduced flexibility of the fingers domain Biochemistry, Jan 2026 DOI: 10.1021/acs.biochem.5c00628
- María Conde-Giménez, Sandra Salillas, María Galiana-Cameo, Juan E. Martínez-Oliván, Alejandro Mahía, Manuel Ledesma, Juan José Galano-Frutos, Ritwik Maity, Adrián Velázquez-Campoy, María D. Díaz-De-Villegas, Ramon Hurtado-Guerrero, Javier Sancho, "Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria", Biomedicine & Pharmacotherapy, 199 (2026), DOI: 10.1016/j.biopha.2026.119371
- Marina Lucic, Johan Glerup, Pierre Aller, Danny Axford, Nicholas Devenish, Jaehyun Park, Anastasiia Shilova, Arturo Landeros De La Isla, Richard W. Strange, Tiankun Zhou, Robin L. Owen, Jonathan A. R. Worrall, Michael A. Hough, "Generation and modulation of catalytically relevant states of a dye-decolourizing peroxidase using time-resolved serial femtosecond crystallography with drop-on-chip mixing and X-ray-driven reduction", Acta Crystallographica Section D Structural Biology, 82 (2026), DOI: 10.1107/S2059798326001658
- Zinnia Bugg, Charlie L. P. Hazlewood, Andrew M. Hemmings, Justin M. Bradley, Nick Le Brun, "Impact of the three-fold channel substitution D131N on kinetics of translocation of Fe 2+ across the protein coat is more severe for human cytosolic H-chain ferritin than for human mitochondrial ferritin", Dalton Transactions (2026), DOI: 10.1039/D5DT02739J
- Giulia Gallo, Antonello Di Nardo, Doreen Lugano, Adam J. Roberts, Bernadette Ataku Kutima, Moses Okombo, Aghnianditya Kresno Dewantari, Florence M. M. Buckley, Gavin J. Wright, James Nyagwange, Bernard Agwanda, Stephen C. Graham, Dalan Bailey, "Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells", Nature, 44 (2026), DOI: 10.1038/s41586-026-10394-x
- [Thesis] Zhichun Lin, "Template technology for biocrystallization" (2026), DOI: 10.26174/thesis.lboro.32048493
- Hamish Mitchell, Boguslaw Nocek, Emily J. Guinn, Jerry Y. Y. Heng, "Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide", Acta Crystallographica Section F Structural Biology Communications, 82 (2026), DOI: 10.1107/S2053230X26001937
- Do-Heon Gu, Danny Axford, James Beilsten-Edmands, Sofia Jaho, Robin L. Owen, "Increasing X-ray energy improves data quality in serial crystallography", Journal Of Synchrotron Radiation, 33 (2026), DOI: 10.1107/S1600577525011063
- John Matheson, Danny Axford, Anna Bergamaschi, Maria Carulla, Nicholas Devenish, Noemi Frisina, Viktoria Hinger, Vadym Kedych, Christopher Lane, Aldo Mozzanica, Eva Gimenez-Navarro, James O'Hea, Dominic Oram, Robin L. Owen, David Perl, Adam Prescott, Bernd Schmitt, Shane Scully, Adam Taylor, Gary Yendell, Graeme Winter, "Experience with the Jungfrau-1M detector at Diamond Light Source", Journal Of Synchrotron Radiation, 33 (2026), DOI: 10.1107/S1600577526000342
- Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill, "Evolutionarily divergent DUF4465 domains have a common vitamin B12 ‐binding function", Febs Open Bio, 369 (2026), DOI: 10.1002/2211-5463.70231
- Belinda J. Mills, Kyle S. Gregory, Gyles E. Cozier, Supannee Taweechai, Eve Loughlan, Glenn A. Mcconkey, R. Elwyn Isaac, Richard Foster, K. Ravi Acharya, "Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P", Journal Of Biological Chemistry, 387 (2026), DOI: 10.1016/j.jbc.2026.111372
- Javier Abellon-Ruiz, Raul Pacheco-Gomez, Jessica Watts, Adam Hart, Robert P. Hirt, Arnaud Basle, Bert Van Den Berg, "BtuJ1, a surface-exposed B12-binding protein in Bacteroidota, functions as an extracellular vitamin reservoir that enhances fitness", Journal Of Molecular Biology, 375 (2026), DOI: 10.1016/j.jmb.2026.169754
- Emma Tarrant, Isabel G. Cormack, Charlotte E. Hunter, Olesia Werbowy, Sebastian Dorawa, Lei Wang, Ida Helene Steen, Ruth-Anne Sandaa, Elísabet Eik Guðmundsdóttir, Bernd Ketelsen-Striberny, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Ehmke Pohl, Stefanie Freitag-Pohl, "Structure, function, and applications of two novel phage recombinases from extreme environments", Nucleic Acids Research, 54 (2026), DOI: 10.1093/nar/gkag069
- Josephine Baunvig Aagaard, Rosaria Gandini, Anne-Sofie Ravn Ballegaard, Bjarke Krogstrup Jensen, Britta Dorn, Amanda Verner Borg Larsen, Anders Lenstrup, Mathias Sønderholm, Michaela Miehe, Wolfgang Pfützner, Thilo Jakob, Gregers Rom Andersen, Christian Möbs, Edzard Spillner, "Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen", Nature Communications, 17 (2026), DOI: 10.1038/s41467-026-69572-0
- Ronald Rios-Santacruz, Harshwardhan Poddar, Kevin Pounot, Derren J. Heyes, Nicolas Coquelle, Megan J. Mackintosh, Linus O. Johannissen, Sara Schianchi, Laura N. Jeffreys, Elke De Zitter, Rory Munro, Martin Appleby, Danny Axford, Emma V. Beale, Matthew J. Cliff, María C. Dávila-Miliani, Sylvain Engilberge, Guillaume Gotthard, Kyprianos Hadjidemetriou, Samantha J. O. Hardman, Sam Horrell, Jochen S. Hub, Kotone Ishihara, Sofia Jaho, Gabriel Karras, Machika Kataoka, Ryohei Kawakami, Thomas Mason, Hideo Okumura, Shigeki Owada, Robin L. Owen, Antoine Royant, Annica Saaret, Michiyo Sakuma, Muralidharan Shanmugam, Hiroshi Sugimoto, Kensuke Tono, Ninon Zala, John H. Beale, Takehiko Tosha, Jacques-Philippe Colletier, Matteo Levantino, Sam Hay, Pawel M. Kozlowski, David Leys, Nigel S. Scrutton, Martin Weik, Giorgio Schirò, "Integrated structural dynamics uncover a new B12 photoreceptor activation mode", Nature, 47 (2026), DOI: 10.1038/s41586-025-10074-2
- E. S. Mackenzie, K. M. Sendra, A. Basle, R. Mazgaj, T. E. Kehl-Fie, K. J. Waldron, "An enzyme's metal preference evolves through redox modulation driven by the cofactor’s secondary coordination sphere", Molecular Biology And Evolution (2026), DOI: 10.1093/molbev/msag040
- Nadine E. M. Myers, Joanna Whittaker, Marie Elodie Hélène Cadot, Julia K. Varga, Marcel Diallo, Jakob Nilsson, Anders Bach, Anja Sandström, Ora Schueler-Furman, U. Helena Danielson, "Identification of ZFTA as a novel KLHL20 substrate and mechanistic insights into fuzzy binding of disordered peptides via biosensor analysis and computational modelling", Chembiochem, 27 (2026), DOI: 10.1002/cbic.70237
- Mariska De Munnik, Amelia Brasnett, Tiankun Zhou, William Myers, Yicheng Wang, Kuntal Chatterjee, Anthony Tumber, Stephen A. Marshall, Philipp S. Simon, Pierre Aller, Anastasiia Shilova, Danny Axford, Hiroki Makita, Daniel W. Paley, Vandana Tiwari, Alexander T. Stead, Sebastian Dehe, Humberto Sanchez, Daniel J. Rosenberg, Roberto Alonso-Mori, Asmit Bhowmick, Junko Yano, Vittal K. Yachandra, Jaehyun Park, Sehan Park, Allen M. Orville, Lennart Brewitz, Jan F. Kern, Christopher J. Schofield, Patrick Rabe, "Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase", Nature Communications, 30 (2026), DOI: 10.1038/s41467-026-69425-w
- James B. Shaum, Miquel Muñoz I Ordoño, Erica A. Steen, Daniela V. Wenge, Hakyung Cheong, Jordan Janowski, Moritz Hunkeler, Eric M. Bilotta, Zoe J. Rutter, Paige A. Barta, Abby M. Thornhill, Natalia Milosevich, Lauren M. Hargis, Timothy R. Bishop, Trever R. Carter, Bryce Da Camara, Matthias Hinterndorfer, Lucas Dada, Wen-Ji He, Fabian Offensperger, Hirotake Furihata, Sydney R. Schweber, Charlie Hatton, Yanhe Wen, Benjamin F. Cravatt, Keary M. Engle, Katherine A. Donovan, Bruno Melillo, Seiya Kitamura, Alessio Ciulli, Scott A. Armstrong, Eric S. Fischer, Georg E. Winter, Michael A. Erb, "High-throughput ligand diversification to discover chemical inducers of proximity", Nature Chemical Biology, 184 (2026), DOI: 10.1038/s41589-025-02137-2
- Maximilian Edich, Yunyun Gao, David C. Briggs, Andrea Thorn, "Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction", Life Science Alliance, 9 (2026), DOI: 10.26508/lsa.202503247
- Guido C. Paesen, Nathaniel S. Chapman, Jonna B. Westover, Cynthia M. Mcmillen, Natalia A. Kuzmina, Emmett A. Dews, Luke Myers, Robert Stass, Joel M. Montgomery, Alexander Bukreyev, Amy L. Hartman, Brian B. Gowen, James E. Crowe, Thomas A. Bowden, "Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain", Plos Pathogens, 22 (2026), DOI: 10.1371/journal.ppat.1013926
- Lídia Dos Passos Lima, Dev Sriranganadane, Daiane Laise Da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius Dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira Da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Counago, Cristina E. Alvarez-Martinez, "A Hanks‐type bacterial kinase, PknS , directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation", The Febs Journal, 9 (2026), DOI: 10.1111/febs.70384
- Joshua P. Smith, Rebecca Smith, Thomas M. Roseveare, Dominic Bara, Alexander J. R. Thom, Ross S. Forgan, Mark R. Warren, Anna J. Warren, Robin L. Owen, Lee Brammer, "Multi-crystal X-ray diffraction (MCXRD) bridges the crystallographic characterisation gap in chemistry and materials science: application to MOFs", Angewandte Chemie International Edition, 1 (2026), DOI: 10.1002/anie.202523233
- Danielle L. Sawyer, Brian E. Eckenroth, Cristian Chavira, Khadijeh Alnajjar, John P. Hanley, Julie A. Dragon, Sylvie Doublié, Joann B. Sweasy, "The S180R human germline variant of DNA polymerase β Is a low fidelity enzyme with reduced flexibility of the fingers domain", Biochemistry (2026), DOI: 10.1021/acs.biochem.5c00628
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