Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy VMXi Contact
Principal Beamline Scientist:
Mike Hough
Tel: +44 (0) 1235 394097
E-mail: Michael.Hough@diamond.ac.uk
Science Group Leader
Dave Hall
Email: david.hall@diamond.ac.uk
Tel: +44 (0) 1235 778926
7 items found for 2026 [total: 34]
Droplet-on-demand tape drive and X-ray emission spectroscopy prototypes for time-resolved serial crystallography on VMXi at Diamond Light Source Iucrj, 13 Sept 2026 DOI: 10.1107/S2052252526005658
Journal Paper I24-Microfocus Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
Ancient nuclear genome duplication events in vertebrates facilitated the functional diversification of ohnologous cytochrome c: Insights from Buergeria frogs Molecular Biology And Evolution, Sept 2026 DOI: 10.1093/molbev/msag243
Journal Paper I03-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy Nature Communications, 17 Jul 2026 DOI: 10.1038/s41467-026-75392-z
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography Communications Chemistry, Jul 2026 DOI: 10.1038/s42004-026-02138-9
YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis Mbio, June 2026 DOI: 10.1128/mbio.00700-26
Journal Paper B21-High Throughput SAXS VMXi-Versatile Macromolecular Crystallography in situ open access
AXIS: a Lab-in-the-Loop machine learning approach for automated detection of macromolecular crystals Iucrj, 13 May 2026 DOI: 10.1107/S2052252526001399
Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state Acta Crystallographica Section D Structural Biology, 82 Feb 2026 DOI: 10.1107/S2059798326000422
- Pierre Aller, Juan Sanchez-Weatherby, Abbey Telfer, Robert Bosman, Nicholas Devenish, Philip Hinchliffe, Sam Horrell, Jophy Ip, Richard Littlewood, Andrew Male, Eva Gimenez-Navarro, Urszula Neuman, Jos J. A. G. Kamps, David Omar, Laura Parkinson, Muthraj Pandi, Nico Rubies, James Sandy, Anastasya Shilova, James Spencer, Jonathan Spiers, John P. Sutter, Amy J. Thompson, Catherine L. Tooke, Ben Williams, Tiankun Zhou, Michael A. Hough, Allen M. Orville, "Droplet-on-demand tape drive and X-ray emission spectroscopy prototypes for time-resolved serial crystallography on VMXi at Diamond Light Source", Iucrj, 13 (2026), DOI: 10.1107/S2052252526005658
- Yuka Asaeda, Sotaro Fujii, Hajime Ogino, Michael A. Hough, Takeshi Igawa, Yoshihiro Sambongi, "Ancient nuclear genome duplication events in vertebrates facilitated the functional diversification of ohnologous cytochrome c: Insights from Buergeria frogs", Molecular Biology And Evolution (2026), DOI: 10.1093/molbev/msag243
- Maya Noureddine, Halina Mikolajek, Nathan Cowieson, Nikos Pinotsis, Paul Robinson, Alexandre Slater, Charles Redwood, Siobhan Loughna, Chris Denning, Fiyaz Mohammed, Katja Gehmlich, "Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy", Nature Communications, 17 (2026), DOI: 10.1038/s41467-026-75392-z
- Elnaz Aledavood, Sandra Ramos-Inza, Jannis Born, Megan Lambert, Hannes Berg, Jan Michael Köhler, Anna Niesteruk, Sridhar Sreeramulu, Amy J. Thompson, Halina Mikolajek, James Sandy, Juan Sanchez-Weatherby, Siyi Wang, Eleanor P. Williams, Martin A. Walsh, Michael A. Hough, Harald Schwalbe, Ana Martínez, Carmen Gil, "AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography", Communications Chemistry (2026), DOI: 10.1038/s42004-026-02138-9
- Clare De'Ath, Sujeet Kumar, Sachi Chhibber, Benjamin F. Cooper, Emilia K. Taylor, Emily Jones, Thomas Lanyon-Hogg, Jani R. Bolla, Christina Redfield, Natividad Ruiz, Georgia L. Isom, "YdbL directly modulates YdbH-YnbE bridge formation to maintain Escherichia coli outer membrane homeostasis", Mbio (2026), DOI: 10.1128/mbio.00700-26
- Aurelien Personnaz, Sihyun Sung, Raphael Bourgeas, Sruthi Unni, Florine Dupeux, Bukunmi Adediran, Rosicler Barbosa, Anne-Sophie Humm, Euan Colaco-Osorio, Jose Antonio Marquez, "AXIS: a Lab-in-the-Loop machine learning approach for automated detection of macromolecular crystals", Iucrj, 13 (2026), DOI: 10.1107/S2052252526001399
- Kelly L. Parker, John D. Clarke, Xiaojiao Liu, Barbara F. Gomes, Lauren E.-A. Eyssen, Nicholas Furnham, Floriano Paes Silva-Jr, Raymond J. Owens, "Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state", Acta Crystallographica Section D Structural Biology, 82, 140 - 150 (2026), DOI: 10.1107/S2059798326000422
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