Small Angle Scattering (SAXS)

Small Angle X-ray Scattering (SAXS) covers the major disciplines of Biology, Chemistry and Physics delivering structural and dynamic information in nanoscience, mesoscopic architectures, supramolecular structures and nucleation/growth of crystals. SAXS is also proving important in archaeological, environmental and conservation sciences,  indicating an ability to span a wide range of scientific disciplines.

Diamond has two synchrotron beamlines dedicated to SAXS, I22 and B21, but several others that carry out SAXS experiments from time to time, I12 (high energy SAXS, 50 - 150 KeV) and I07 (GiSAXS). We also have an offline instrument (labSAXS), that the user community can bid for time on via standard, BAG and Rapid Access modes. The labSAXS instrument will also carry out sample environment testing for I22 and other beamlines.

Software Improvements

Dawn, with these tools, can be downloaded from www.dawnsci.org. The latest release of Dawn, includes an extensive set of data reduction tools for SAXS data. A detailed description of these tools can be found in the paper by Pauw et al. A paper concerning the processing perspective available in Dawn has been published recently and has been highlighted on the Diamond website.

New to SAXS?

  • The Beginners Guide to SAXS provides useful information on what is possible, helpful hints and tips for experiments and some basic background on our beamlines, I22 and B21. It now includes links to the lectures from our recent Basic SAS Training School. The Beginners guide also includes a useful reference book list for Small Angle Scattering.
  • A nice introduction to the technique was been printed in the 2015 issue of our "Inside Diamond" Magazine. You can find it on pages 20-21 of the magazine.

Latest B21 publication


A novel cell-penetrating lipopeptide for DNA binding, self-assembly, and delivery into HeLa and pluripotent stem cells
Lucas R. De Mello, Tâmisa seeko bandeira Honda, Valeria Castelletto, Patrícia terra Alves, Sang Won Han, Emerson Rodrigo Da Silva, Ian W. Hamley
Journal Of Peptide Science, 32 Mar 2026 DOI: 10.1002/psc.70085
Journal Paper B21-High Throughput SAXS open access

Latest I22 publication


Nanostructural evolution during carious and demineralisation process of human dentine using small angle X-ray scattering tensor tomography
Tayyaba Rabnawaz, Nathanael Leung, Leonard C. Nielsen, Robert A. Harper, Richard M. Shelton, Gabriel Landini, Tim Snow, Andy Smith, Nick Terrill, Marianne Liebi, Tan Sui
Journal Of Structural Biology, 218 Mar 2026 DOI: 10.1016/j.jsb.2025.108284
Journal Paper I22-Small angle scattering & Diffraction

Latest LabSAXS publication


Enhanced third-order optical nonlinearity in a dipolar carbene-metal-amide material with two-photon excited delayed fluorescence
Ikechukwu D. Nwosu, Lujo Matasović, Tárcius N. Ramos, Nguyen Le Phuoc, Giacomo Londi, Alexander J. Gillett, Daniel T. W. Toolan, Charles T. Smith, George F. S. Whitehead, Mireille Blanchard-Desce, Jonathan Daniel, Mikko Linnolahti, Yoann Olivier, Alexander S. Romanov
Communications Chemistry, 2 Feb 2026 DOI: 10.1038/s42004-026-01928-5
Journal Paper labSAXS-Offline SAXS and Sample Environment Development open access