Near Native Cell Imaging
- Generates 3D slices through the sample
- Collects data on intact and unstained cells through the entire cell thickness
(up to 8 μm) - Probes a wide range of sample types from bacteria to whole mammalian cells
Applications of cryo soft X-ray tomography (SXT)
Technique
Structural Cell Biology
- Studies the effect of drugs on living cells
- Follows the effects of biological processes on the cell e.g. starvation
- Monitors cell regulation processes
- Investigates impact of nanoparticles on cells
Cell Infection Process
- Studies cell infection
- Images viral particles within infected cells
- Examines changes to cell organelles post-infection
- Explores host-pathogen interactions
Functional Studies of Cellular Processes
- Performs correlative studies with cryo-fluorescence microscopy
- Reveals localisation of fluorescent proteins within complex organelles
- Captures processes of dynamic membrane trafficking.