Why choose

Why choose XChem at Diamond for your research?

XChem: X-ray structure-accelerated, synthesis-aligned fragment medicinal chemistry

At Diamond, our world-class XChem facility provides a streamlined, secure, and effective route to fragment screening. The co-location of the dedicated XChem laboratory and beamlines allows us to significantly reduce the time to structural determination. Our dedicated services, unique processes, tailored software, and automated systems ensure seamless data recording and tracking from initial crystal cultivation through to data analysis. Throughout your research journey, our expert scientists are available to advise, train, and support you every step of the way.

Benefits

Benefits

Fragment Screening via X-ray crystallography:

  • High-resolution, robust and reliable results
  • Direct structural feedback of the ligand-target interaction at atomic level
  • Fragment validation, to enable quick progression through the research pipeline
  • Typical hit rates of between 3-20%
  • Fast and cost-effective structural determination 

XChem at Diamond: 

  • Cost-effective access to innovative (first-of-its-kind) facilities
  • Co-location of lab and beamline speeding up time to results
  • Optimised processes for soaking 100s of compounds a day
  • Automated data collection for rapid & effective throughput
  • Secure sample tracking and data management
  • Readily available libraries of compounds 
  • Support from XChem experts

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