- Probe microstructures over different length scale ranges, from polypeptides to large complexes
- Determine oligomerisation state of a protein or protein complex
- Characterise multi-domain proteins using data from subcomponents of modular proteins or complexes (eg. for targeted antibodies)
- Investigate conformational changes associated with ligand binding
- Study flexible proteins and samples that are not amenable to crystallisation
- Identify suitable conditions for crystallisation
- Validate crystal structures in solution state
- Facilitate large molecule drug discovery
- Assess changes due to external environments (e.g., pH, temperature) and the effects of excipients, and coatings.
Llama-derived fusion protein to prevent COVID-19
Researchers from UCL have developed a llama-derived nanobody fusion, C5-Fc, that targets the SARS-CoV-2 spike protein’s receptor-binding domain (RBD). Using SAXS and SANS at Diamond Light Source, they revealed its stable, compact structure and broad neutralising potential—offering a promising route for next-generation COVID-19 therapeutics.
