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Applications of MX

Technique
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  • Standard MX data collection
  • Fully automated data collection (UDC)
  • Experimental phasing (SAD, MAD)
  • Automated sample centring and locating the best diffracting part (grid scans, X-ray centring)
  • Collection of radiation-sensitive samples (line scans, helical data collection)
  • In situ data collection (beamline VMXi)
  • Micro/nanofocus MX data collection (beamline VMXm)
  • Serial synchrotron crystallography (SSX, beamline I24). 

MX case studies

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From Protein to Structure with Diamond services

MiroBio partnered with Diamond Light Source to solve the structure of a novel PD1-targeting antibody. Using macromolecular crystallography, the team revealed the atomic-level binding interface—advancing therapeutic development for autoimmune diseases.
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T-Cell Receptors For Cancer Immunotherapy

Scientists from Immunocore and GlaxoSmithKline used macromolecular crystallography at Diamond Light Source to determine how different T-cell receptors bind the same cancer antigen—advancing precision immunotherapy design.
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Pre-crystallisation screening for membrane protein crystallisation

UCB used the LCP-FRAP technique at Diamond Light Source to assess membrane protein diffusion in lipidic cubic phase—enabling faster screening and improved crystallisation outcomes for structural biology projects.

Related techniques

Fragment Screening - XChem
Crystallisation Facilities
Cryo-Electron Microscopy at eBIC for Industry
Cryo-soft X-ray tomography (cryo-SXT)
Protein SAXS (bioSAXS)

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