MX Beamlines

I03 is a high throughput tuneable beamline. In addition, its containment infrastructure allows experiments on biological agents in Hazard Groups 2 and 3.

Benefits:

• High photon flux
• Fast data collection
• Fully automated data collection via X-ray centring 

Best For:

• Standard data collection
• Experimental SAD and MAD phasing
• Hazard Groups 2/3 biological samples

I04 is a high throughput tuneable beamline with a variable beam focus from 5 to 100 microns.  

Benefits:

• Microfocus beam
• Fast data collection, Fully automated data collection via X-ray centring

Best For:

• Standard data collection
• Experimental SAD and MAD phasing
• Small or disordered samples
• Samples in LCP

I04-1 is a high throughput fixed wavelength beamline associated with the XChem platform.

Benefits:

• Fast and fully automated data collection

Best For:

• Standard data collection
• Experimental SAD phasing
• Fragment screening (XChem)

I24 is a high throughput tuneable beamline with variable microfocus beam from 6 to 50 microns. The beamline has a dual goniometer endstation allowing for both cryo and in situ modes of data collection.

Benefits:

• Microfocus beam
• High photon flux density
• Fixed target crystallography
• Flexible data collection mode
• Fast data collection

Best For:

• Standard data collection
• Experimental SAD and MAD phasing
• Small and disordered samples
• Samples in LCP
• Serial synchrotron crystallography

VMXm is a micro/nanofocus MX beamline aimed at atomic structure determination in cases where the production of significant quantities of protein material and crystals is problematic. 

Benefits:

• Can be used in cases where the production of significant quantities of protein material and crystals is problematic.

Best For:

• Structure determination from extremely small crystals 
• Micro/nanofocus MX beamline
• Novel X-ray optics and electron beam imaging methods

This Versatile Macromolecular Crystallography in situ (VMXi) beamline is an entirely automated facility for characterisation of, and data collection directly from, crystallisation experiments in situ.

Benefits:

• Entirely automated facility and for in situ experiments.

Best For:

• Characterisation of crystallisation experiments
• In situ data collection

I23 is a long-wavelength tuneable beamline dedicated to phasing experiments. The whole endstation, including I23 bespoke Pilatus detector, is under vacuum to minimise absorption and scattering effects.

Benefits:

• Operational wavelength range from 1.5 to 4 Å
• Access to the absorption edges of physiologically important elements

Best For:

• Experimental phasing on native samples (i.e. S and P)
• Phasing of large macromolecular complexes
• Ion binding characterisation (e.g. Ca, K or Cl)